Hypoxia and tissue destruction in pulmonary tuberculosis
نویسندگان
چکیده
Moerida Belton, Sara Brilha, Roido Manavaki , Francesco Mauri, Kuldip Nijran, Young T. Hong, Neva H. Patel, Marcin Dembek, Liku Tezera, Justin Green, Rachel Moores, Franklin Aigbirhio, Adil Al-Nahhas, Tim D. Fryer, Paul T. Elkington, Jon S. Friedland 1 Section of Infectious Diseases and Immunity, Imperial College London, UK 2 Department of Radiology, School of Clinical Medicine, University of Cambridge, UK 3 Department of Histopathology, Hammersmith Campus, Imperial College London, UK 4 Radiological Science Unit Charing Cross Campus, Department of Nuclear Medicine, Charing Cross Campus, Imperial College NHS Trust, London, UK
منابع مشابه
Hypoxia and tissue destruction in pulmonary TB
BACKGROUND It is unknown whether lesions in human TB are hypoxic or whether this influences disease pathology. Human TB is characterised by extensive lung destruction driven by host matrix metalloproteinases (MMPs), particularly collagenases such as matrix metalloproteinase-1 (MMP-1). METHODS We investigated tissue hypoxia in five patients with PET imaging using the tracer [18F]-fluoromisonid...
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